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Vitamin D deficiency does not cause disease

Filed under: Health — anlactunay @ 8:59 AM

Vitamin D deficiency does not cause disease
RESEARCHERS who conducted a large systematic review of studies on 25-hydroxyvitamin D (25(OH)D) say the association between 25(OH)D and health disorders reported in many observational studies are not causal. The research, published in The Lancet Diabetes and Endocrinology, included 290 prospective cohort studies (279 on disease occurrence or mortality, and 11 on cancer characteristics or survival), and 172 randomised trials of major health outcomes and of physiological parameters related to disease risk or inflammatory status. The researchers wrote that evidence from the review suggested that low 25(OH)D could be the result of inflammatory processes involved in the occurrence and progression of disease. They said most prospective studies reported moderate to strong inverse associations between 25(OH)D concentrations and cardiovascular diseases, serum lipid concentrations, inflammation, glucose metabolism disorders, weight gain, infectious diseases, multiple sclerosis, mood disorders, declining cognitive function, impaired physical functioning, and all-cause mortality. High 25(OH)D concentrations were not associated with a lower risk of cancer, except colorectal cancer. “Results from intervention studies did not show an effect of vitamin D supplementation on disease occurrence, including colorectal cancer … An exception would be slight gains in survival after the restoration of vitamin D deficits due to lifestyle changes induced by ageing and ill health”, the researchers wrote. They said five trials were under way testing whether vitamin D supplementation can reduce the risk of cancer, cardiovascular diseases, diabetes, infections, declining cognitive functions, and fractures. “The first results are not expected before 2017, but these studies have the potential to test our hypotheses”, they wrote. An accompanying editorial said that despite the growing body of evidence indicating that vitamin D was unlikely to prevent non-skeletal disorders, there was “strong support for its use from many prominent members of the research community, which is fuelled by the relatively low toxicity of vitamin D, the glimmer of positivity from some trials, and the large body of evidence from prospective observational studies”. However, the editorial said vitamin D might not be safe in all settings and this was a concern, given the large number of people taking vitamin D supplements.




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